have you try to install latest SEP 12.1.5 ?
Seems many issue are resolved in SEPM 12.1.5
Outlook Express cannot send or receive email when Internet Email Auto-Protect is enabled
Fix ID: 3500332
Symptom: Sending or receiving an email with Outlook Express results in error 0x800ccc0E when the Internet Email Auto-Protect feature is enabled.
Solution: Resolved an issue in the SymTDI driver routing table lookup logic.
Microsoft Outlook downloads full email instead of headers only when Symantec plugin is enabled
Fix ID: 3155464
Symptom: Microsoft Outlook is configured to download email headers only. When the Microsoft Outlook Auto-Protect plugin is loaded, Outlook downloads the full email.
Solution: Modified the Microsoft Outlook Auto-protect plugin to skip processing the message when only headers are downloaded. The plugin then processes and scans full messages and attachments when Outlook downloads them
http://www.symantec.com/business/support/index?page=content&id=TECH224706