Ok, in that case try following procedure for LU reinstall on SEPM 12.1:
1. Remove Live update from "Add/ Remove Programs"
2. Reboot the machine
3. In Windows Explorer, if they are present delete the following folders, without saving the existing content:
- C:\ProgramData\Symantec\LiveUpdate
- C:\ProgramData\Application Data\Symantec\LiveUpdate
- C:\Program Files (x86)\Symantec\LiveUpdate
4. Install LU using lusetup.exe (execute with local admin rights - build in administrator)
5. in D:\Program Files\Symantec\Symantec Endpoint Protection Manager\bin:
- Type lucatalog -cleanup and press Enter.
- Type lucatalog -forcedupdate and press Enter.
6. in C:\Program Files (x86)\Symantec\LiveUpdate start luall.exe (execute with local admin rights)