Hello,
I agree with Sebastian's comment.
How many clients is this SEPM managing?
In case you are storing 30 days worth of definitions - how many revisions are set to be stored on SEPM - 90? Symantec releases around 3 defs updates every day = 30days/90 revisions
90 revisions would mean 180 defs revisions stored in reality (64 and 32bit) these are around 230MB compressed and additionaly around 400 MB uncompressed - that gives you 180 x 630MB = approx. over 110GB only for the AV Defs - so this is expected.
Try to limit the stored revisions if they are not really required by the clients:
Once you changed the number of revisions to keep, just run LiveUpdate: this should apply your changes and automatically delete oldest definitions.
How to change the number of downloaded content revisions that are retained by the Symantec Endpoint Protection Manager versions 11.0. or 12.1
http://www.symantec.com/docs/TECH104845
Maintaining the database
http://www.symantec.com/docs/HOWTO55337
Disk Space Management procedures for the Symantec Endpoint Protection Manager
http://www.symantec.com/docs/TECH96214
Changing the log settings to reduce the size of the database.
http://www.symantec.com/docs/TECH105238
Check this Thread: https://www-secure.symantec.com/connect/forums/sepm-content-folder-size
Hope that helps!!