you can run the Symhelp offline, however to check the files againg Symantec reputation server the tool need internet connectivtiy.
To complete a scan that was run without connectivity to the Symantec Reputation database run SymHelp on a system with access to the Internet and from the Home page, in the menu at the top, choose File > Open Report and open the saved .sdbz. Select the 'Threat Analysis' tab and then click the 'Complete Report' button.
http://www.symantec.com/business/support/index?page=content&id=TECH215519