What are the events in the event viewer ? Any system errors or warnings?
Also you can try runnig Rootkit revealer from Sysinternals and see if there is any kind of rootkit blocking it.
There can be other reason for this as well its not always virus.. Try emoving the FDD and see if your computer is working fine...
Even in SEP there is check for Floppy Disk ( Check floppies when computer shuts down---it is in File System Auto-Protect Advanced -Floppies )...Disable that feature and check it again.