HI,

Kindly provide log.Liveupdate ?

Symantec Endpoint Protection Manager (SEPM) 12.1 is not updating 32 or 64 bit virus definitions

http://www.symantec.com/business/support/index?page=content&id=TECH166923

The SEPM does not update virus definitions. Liveupdate not working on the Symantec Endpoint Protection Manager 12.1

http://www.symantec.com/business/support/index?page=content&id=TECH183178

Follow this doc and re-install and re-register liveupdate to SEPM

http://www.symantec.com/docs/TECH102609

Hello,

What version of Liveupdate Administrator (LUA) are you running?

Make sure you are running the Latest version of LUA 2.3.2, Check this Article - 

LiveUpdate Administrator (LUA) version 2.3.2 is now available

Also, Make sure the SEPM and LUA are not on the same server.

LiveUpdate Administrator 2.x and Symantec Endpoint Protection Manager on the same computer

http://www.symantec.com/docs/TECH105076

and 

Follow the Steps provided in the Article below:

Endpoint Protection 12.1 Clients fail to apply Virus and Spyware Protection definitions from LiveUpdate Administrator 2.x

http://www.symantec.com/docs/TECH196873

Secondly, check this Article on - 

LiveUpdate Administrator 2.x Server Connection Recommendations

Hope that helps!!

I'd highly recommend reviewing the below article for how to troubleshoot LiveUpdate on a SEPM

http://www.symantec.com/docs/TECH105924

The article contains instructions on how to locate the log files (log.liveupdate and sesmlu.log) that would assist Symantec Support if it gets that far.

Double check the configuration of LUA.

Whether  it is configured to download and distribute SEPM updates?

Whether the download and distribution schedules are running fine?

Is there any error messages are present in SEPm console-->admin-->servers tab?

Hi Shiva89,

Do you still require assistance with this?  The thread is still marked "needs help." 

Please be sure to supply as much detail as possible about your products and versions, specific error messages, etc.