how many clients?

you can use 1 SEPm and at other location you can use GUP if the clients are less

Hello,

What is the bandwidth between these Sites?

Incase, you are in the Planning stage of SEPM and it's Architecture in your Environment, this Article would surely assist you:

Getting up and running on Symantec Endpoint Protection for the first time

http://www.symantec.com/docs/HOWTO55274

Also, check these 2 Threads:

https://www-secure.symantec.com/connect/forums/symantec-endpoint-protection-management-multi-site-setup

https://www-secure.symantec.com/connect/forums/running-sep-product-multiple-sites

Hope that helps!!

Hi,

Hope you are doing gr8..

As you have said that you have only 50 clients on one site, So I would advise you that you  can go for only one SEPM server, From that server you can manage both site. 

Hi,

For easy administration and to save bandwidth you should implement 1 SEPM & 1 GUP only.

If you need failover & loadbalancing/ Replication in that case 2 SEPM's one at each site. But available bandwidth should be taken into consideration.

By looking at scenario 1 SEPM & 1 GUP should satisfy business requirement.

GUP is better solution to manage the remote location clients.

https://www-secure.symantec.com/connect/downloads/create-gup-symantec-can-help-conserve-bandwidth-clients-remote-location

It will be easiest to setup one SEPM and than GUPs at your remote location(s) for content distribution.