Hello,
I believe you are running the SEP 12.1 clients.
Are the clients Managed OR Unmanaged?
In case they are managed and this issue is occurying on all client machines, then do check if the SEPM is updated.
In case they are unmanaged client, please check if these clients are connect to the internet.
Symantec Endpoint Protection: LiveUpdate Troubleshooting Flowchart
http://www.symantec.com/docs/TECH95790
More detailed information about why LiveUpdate failed can be found in the following log file:
<drive></drive><Drive>:\Documents and Settings\All Users\Application Data\Symantec\LiveUpdate\Log.LiveUpdate
LiveUpdate Engine creates a log file called Log.Lue. This log can be found in the following location when LUE was run on a self-managed client:
On Windows XP and Windows server 2003:
C:\Documents and Settings\All Users\Application Data\Symantec\Symantec Endpoint Protection\<silo_id>\Data\Lue\Logs
On Windows Vista, Windows 7, and Windows Server 2008:
C:\Program Data\Symantec\Symantec Endpoint Protection\<silo_id>\Data\Lue\Logs
Hope that helps!!