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On January 5th, 2015, Symantec Endpoint Protection version 11.0.x will reach end of support life. Virus definitions and security updates will cease to be published to LiveUpdate and general support for the product will no longer be provided.
The initial end of support life date was originally scheduled for January 5th, 2014. All customers were provided a complimentary extention. No further extentions will be provided.
It's strongly recommended to upgrade to SEP 12.1, RU5 is the latest release.
To know the best practice I would recommend you to go through the following article.
https://www-secure.symantec.com/connect/articles/sep-11x-sep-121-upgrade-process-graphical-overview
Important note: The SEP 12.1 SEPM upgrade installer requires three times the current database size (sem5.db) if upgrading from pre-12.1 SEPM with the embedded database only.
Reference : http://www.symantec.com/docs/TECH162730
After successful SEPM upgrade plan for SEP client upgrade. If clients are high in number plan it in phase wise.
Auto upgrade can be easiest way to upgrade existing clients.
Check these article also:
Upgrade or migrate to Symantec Endpoint Protection 12.1.5
http://www.symantec.com/docs/TECH224034
FAQ: Upgrading Symantec Endpoint Protection 11.x to version 12.1.x
http://www.symantec.com/docs/TECH207274