Symantec Endpoint Protection RU6 MP1 (11.0.6100) provides fixes since the release of RU6 and RU6a. This maintenance patch cannot be installed over any versions of Symantec Endpoint Protection or Symantec Endpoint Protection Manager prior to RU6. It must be installed over RU6 or RU6a.
RU6MP1 is a Maintenance patch and not a maintenance release, A MP can only be installed on the main build. You can install RU6 over RTM or MR3 or MR4MP2 but not RU6MP1. For that you need to have RU6
It is not recommend to upgrade directly from RU5 or MR4 to RU6MP1
This migration path is not supported.
Possible effects after a direct upgrade to RU6MP1 from a lower version [except RU6]:
Schema Corruption.
Possible dll corruption.
Policies Corruption.
Network breakdown.
Challenges with uninstalling SEP.
So what you need Upgrade the clients to RU6 and then upgrade to RU6MP1.