You can redirect SEP 12.1 Agent Def files (likewise SEP 11, but process is a little different), but ONLY the traditional AVDefs, in other words your SEP Agent for such scenarios can only be a "AV Only" SEP Agent. This is because the newer technologies (SONAR, IPS etc) have been poorly implemented in such a way they do not permit relocation, as their location values in the registry are hard-coded per ever engine and def update.
The other problem is, it's a very manual process as it can only be done post-install, and if you were to ever upgrade SEP Agent "over the top" from memory it restores to default OS drive location, meaning you need to do it again.
Essentially perform an AV only SEP Agent install (with no Defs included in the package as it's pointless) and then untick Tamper Protection (if enabled), do a smc -stop, change the following two reg key values to something else that respects the existing folder structure, i.e. D:\SEPDefs and D:\SEPDefs\Definitions\VirusDefs respectively, smc -start, give it time to update.
Done.