What steps have you take so far?
How to run the Threat Analysis Scan in Symantec Help (SymHelp)
http://www.symantec.com/docs/TECH215519
Security Response recommendations for Symantec Endpoint Protection 12.1 settings
http://www.symantec.com/docs/TECH173752
Security Response recommendations for Symantec Endpoint Protection 11.x settings
http://www.symantec.com/docs/TECH122943
Security Best Practice Recommendations
http://www.symantec.com/docs/TECH91705
How to scan in safe mode with Symantec Endpoint Protection 12.1 RU1 MP1 and earlier
http://www.symantec.com/docs/TECH176971
Scanning in Safe Mode is no longer possible with 12.1 RU2 and later
http://www.symantec.com/docs/TECH205872
Is your system infected? Symantec tools to help clear an infection
https://www-secure.symantec.com/connect/forums/your-system-infected-symantec-tools-help-clear-infection
Symantec Endpoint Protection – Best Practices
http://www.symantec.com/page.jsp?id=stopping_malware