Yes, with 11.x, you could automatically clear.
This changed with 12.1. 12.1 automatically clears itself once it deems the threat has been removed.
Stick in a "clean" cd and run a full scan. When it comes up clean, it will auto clear in the SEPM as well.
https://www-secure.symantec.com/connect/forums/sep-121-cannot-clear-still-infected-status