I work for a non-profit supervising two System Administrators and manage 260 desktop/laptops, 24 servers, hardware based firewall (mainaining packet filter rules, web content proxy, anti-virus, anti-spam, IPS). About 24 locations across the State.
Also responsible for File/Print servers, Exhange FE/BE, WSUS, SMS 2003 (upgrading at the moment to SCCM 2007 R2), BackupExec, SEPM/SEP (upgraded from SCS 3.x, upgraded from SAV 8/9/10), SQL, Oracle, HP Insight Manager, VMware ESX, Trend Micro, Exclaimer, VOIP phone system (currently upgrading), Retail POS computer registers, bar code printers, several brands of security camera DVR systems, Terminal Services in application mode for WYSE thin clients (testing now to convert old shared computers to replace/deploy about 120 thin clients), Blackberry Enterprise Server, four custom applications for HR, Finance and Marketing.
Finally implemented a NetFlow Analyzer server to "know my flow" (what a big help). I'm a jack of all trades, master of none. :-)