I have read the comments posted here and thought I would share our experience.
We are now running SEP 12 RU1 and are very pleased with it. Several of the issues we were having were actually incorrect settings migrated from previous versions.There are also a lot of issues resolved with the RU1.
That said, I have also had some negative experiences with the first level of support when I have called in. However, I did speak to my account team and escalated the call ticket. The representative I was assigned after the escalation was FANTASTIC. He was very familiar with the product, not afraid to say he needed to research something further and get back to me, patient, and helped with several issues.
We are running on a virtual server (Windows Server 2008 Datacenter). Clients range from a small number of Win XP's. Vista 32 bit and Win 7 64 bit. We have nearly 2000 clients spread over the whole state, in over 100 locations. We battle bandwidth issues and need to minimize impact on our clients during the work day. Using GUPs (Group Update Providers) correctly has helped with many of our issues. However, just correcting a few settings fixed most of the problems.
I will also add that managing SEP for our branch is only one of my duties. Since it is NOT my only duty, I do require more "hand holding" than those folks who have a dedicated responsibility to SEP and can concentrate on just it. I need SEP to run without a lot of intervention on my, and my other team members, part. We have made huge progress toward this goal. A little more work this week and we should be there.
Comparted to past upgrades, I think the leap from 11 to 12 and now to 12.1.1000.157 RU1, have been by far the easiest.
I encourage you to contact your Sales Manager and/or Systems Engineer and ask for their assistance. I also specifically asked for someone state side. This helped with communication as well.
Hope this is an encouragement to many of you having problems.