Many thanks for the Idea, Matthew!

Here is an excerpt from "Managing LiveUpdate Administrator 2.x Space Usage" that may help at present:

https://www-secure.symantec.com/connect/articles/managing-liveupdate-administrator-2x-space-usage

 ....

An "emergency purge" option may be added to a future release of LUA.  There is a Connect Forum "Idea" (proposed enhancement request) that can be supported by those who wish to voice their interest in such an option: "Purge Now" Button for LiveUpdate Administrator 2.x

The best current solution, if it is strongly believed that an existing DC contains files that it should not:

1.Backup the LUA 2.x server's settings
2.Backup the contents of the DC
3.Delete the DC in LUA's Configure / Distribution Centers GUI
4.Afterward, re-create the DC with the same location, name, etc
This will wipe out all of the current contents and replace them with only the current, known-good, valid materials from the LUA server's Manage Updates directory.

There are a couple of existing Ideas that you may wish to vote upon.....

There are a number of proposed changes to the way that LUA handles its content.  Admins may wish to cast a vote in support of the following enhancements to the way LUA manages updates and displays information about them:

•LiveUpdate Administrator 2.x - Improved Update Management
•"Hit Counter" Page for LiveUpdate Administrator 2.x
•LUA 2.x Ability to Manually Replace Files when Distributing