Internet Explorer 6 may have taken its path to retirement but it still remains a good target for exploits, as we can see from JS.Sykipot. This zero-day was found on March 8th and it exploits a vulnerability in some Internet Explorer versions (CVE-2010-0806 , BID 38615) that can lead to remote code execution. Upon successful exploitation, JS.Sykipot will download and run Backdoor.Sykipot, which is a back door capable of communicating with its control server to receive and run several commands.
In my tests, the exploit worked successfully on IE6...