Hello,
Did you check the this Symantec Knowledgebase Article:
Many Unexpected Pop-Ups from Symantec Email Proxy are Displayed
Those pop-ups are making visible to end-users the messages from the remote mail server. There is something on your computer that is sending mail, and remote servers are bouncing it back as spam.
Chances are that the computer is infected and is sending out spam. See the following article provided above.
I recommend putting the very latest definitions on to that computer, isolating it from the network, and performing a full system scan in safe mode.