Folow this
1. Stop the SEPM server service.
2. Go to "…\Inetpub\content\{C60DC234-65F9-4674-94AE-62158EFCA433}" folder and deleted all the sub folders
3) Go to C:\Program Files\Common Files\Symantec Shared\SymcData\ and delete the following folders:
sesmipsdef32
sesmipsdef64
sesmvirdef32
sesmvirdef64
4)In the registry, navigate to HKEY_LOCAL_MACHINE\SOFTWARE\Symantec\InstalledApps.
Delete these keys
SymcData-sesmipsdef32
SymcData-sesmipsdef64
SymcData-sesmvirdef32
SymcData-sesmvirdef64
5). In the registry, navigate to and delete the following keys:
HKEY_LOCAL_MACHINE\SOFTWARE\Symantec\SharedDefs\SymcData-sesmipsdef32
HKEY_LOCAL_MACHINE\SOFTWARE\Symantec\SharedDefs\SymcData-sesmipsdef64
HKEY_LOCAL_MACHINE\SOFTWARE\Symantec\SharedDefs\SymcData-sesmvirdef32
HKEY_LOCAL_MACHINE\SOFTWARE\Symantec\SharedDefs\SymcData-sesmvirdef64
6). Start the SEPM service back up.
7) Put the jdb
Symantec Endpoint Protection Manager 11.x is not updating 32 or 64 bit virus definitions. http://service1.symantec.com/support/ent-security.nsf/docid/2008041516215948