Hi SupremeFTW,
Basically, you do not have to manually configure the proxy settings on the SED client. The Symantec Encryption Desktop (SED) automatically determines your email account settings and creates a PGP Messaging service that proxies the email for that email account. Let me know if you are having issue with automatic account discovery.
You must disable the SSL /TLS settings in your email client otherwise SED does nto proxy your email. But that does not mean that the connection is not encrypted. The SED automatically attempts to upgrade any unprotected connection to SSL /TLS. In other words, SED will take over this task.
For more information, you can read the following KB article:
http://www.symantec.com/docs/TECH149647
Hope it helps.
Best Regards,
Bipin