Sandip - why? We ghost machines, physical machines, and as long as the correct registry keys are deleted, it recreates new ones and life is fine.
Everything else is cloned on a VM server here and all works ok. I've not done SEP, but then we so RARELY use the templates to put out new machines, it's simply not been done yet.
I guess at this point, I fail to see the difference between a Ghost image and a VM "image"............. as long as those keys are deleted and allowed to be recreated (and with RU5, that file mentioned in the KB as well)
You have to prep the clone anyway with names and IP addressing, etc. - what's the diff, I'd ask?