Sorry for the long delay in responing, but you posted in the wrong forum.
This KB article may address your issue.
Error: "The handle is invalid" when attempting to launch a process blocked with Application Control in Symantec Endpoint Protection
http://www.symantec.com/business/support/index?page=content&id=TECH152425&actp=search&viewlocale=en_US&searchid=1314285175818
I am going to move this thread over to the Endpoint Protection forum for you.
Best,
Thomas