Hi Manikandan,
Thank you for posting in Symantec community.
I would be glad to answer your query.
Symantec Endpoint Protection 12.1 is compatible with Symantec Endpoint Encryption 8.2. It is not compatible with any previous version of Symantec Endpoint Encryption. If Symantec Endpoint Protection 12.1 is installed with any version of Symantec Endpoint Protection before 8.2, the computer may halt with a blue screen error.
Legacy versions of Symantec Endpoint Protection are compatible with all versions of Symantec Endpoint Encryption.
Reference: Is Symantec Endpoint Protection 12.1 compatible with Symantec Endpoint Encryption?
http://www.symantec.com/docs/TECH166696
About Symantec Endpoint Protection Manager compatibility with other products
http://www.symantec.com/docs/HOWTO81335
Addressing Symantec Endpoint Protection compatibility issues
http://www.symantec.com/docs/TECH103811
On my test machine I have SEP 12.1 RU2 along with Encryption 10.3.0 MP1, EV and Bakcup exec and I can say all they are running fine.
However you can cross verify about Backup exec.cloud and EV.