Trying to configure the mail notification, what the steps i can perform?
Any of the extra port is require to open for it?
Add the email server detail in SEPM.
Telnet the port 25 if it work then no need to open any other port.
If you have configure SMTP you need to open port 25
To utilize email alerts, an existing SMTP server must be present in the environment
Seems like a straightforward question, the SEP knowledegbase provides the answers, please do check it:
http://www.symantec.com/business/support/index?page=productlanding&key=54619