You may want to review the detection rule best practices doc:
http://www.symantec.com/docs/HOWTO59040
I'd recommend that you create two software resources, one for 32-bit and one for 64-bit. The 32-bit software resource should have a 32-bit applicability rule, and the 64-bit should have a 64-bit applicability rule. And each, of course, would also have a detection rule to see if the application is installed.
For the detection rule, if you want to say that the hotfix is installed if either file version is present, use the following structure:
AND (the default AND condition)
***OR (that you add)
******File Version
******File Version
With this in place, you can add both software resources to a single managed software delivery policy, apply it to all Windows Workstations, and the applicability rules will determine which software resource to run. The detection rules, of course, will determine if its installed.
Does this help?