I need to exclude certain .exe files specific to two computers in SEPM. Can anyone guide how to create that exclusion for extensions
You need to create new group and move both computer in particular group and assgin policy.
How to create an application exception in the Symantec Endpoint Protection Manager
http://www.symantec.com/docs/HOWTO61213
Creating exceptions for Symantec Endpoint Protection
http://www.symantec.com/docs/HOWTO80919
Creating Application Control Exclusions in Symantec Endpoint Protection 12.1
https://www-secure.symantec.com/connect/articles/crreating-application-control-exclusions-symantec-endpoint-protection-121