Hi,

I have about 180 servers and i want to disable Network Threat Protection (IPS) from SEPM without need to restart the servers.

Thanks

Network Threat Protection required reboot.without reboot you can't remove NTP feature.

How to add or remove features to existing Symantec Endpoint Protection (SEP) client installations

Sooooo, as James007 correctly states above, full removal of NTP from the client requires a reboot.

However, just withdrawing the IPS policy from the servers will prevent it from blocking traffic (so while it's still loaded, it won't do anything).  It's up to you whether or not this is sufficient.

You can not uninstall IPS without a reboot. You can setup an auto upgrade to remove and not force a reboot but IPS won't be fully removed until the machine is physically rebooted. 

If you want to disable it, just withdraw the policy.

If you want to remove the component, a reboot is needed.

Withdrawing a policy from a group

I believe disabling the component is the right choice in my case as .Brian mentioned but can i disable it to specific server from SEPM? What would be the effect on the servers when i disable IPS? Would i still protected? 

You can disable on specific serversif you wish but you won't be protected against malicious network traffic which is what the IPS does. You would only be relying on the AV component

To disable IPS on a single machine, you'll have to move it into a group of its own and withdraw the IPS policy from that group (as I mentioned earlier).

The level of protection you have left depends on what else is installed and how it's configured.  In a typical install on a server with the "Full Protection for Servers" feature set chosen, you still have AV, Download Protection, SONAR, A&DC, and the FW to protect the machine with.  Configure these as appropriate.