Hello,
First of all, you can’t specify which Software/App to block, you will need to block all the Apps listed in the Application Monitoring.
In order to do it, create a detection based on "Protocol and Endpoint Monitoring", select Endpoint Applications: Application File Access. That’s all for detection.
Then in Groups tab, add a rule to select the users that will be restricted to use the Applications (e.g Sender/User Matches Pattern).
To finalize go to last tab of policy creation, Response. There add a Response Rule to Block.
Bear in mind that the