Whew, this is one we have been fighting for quite a few versions of SEP. I apologize to you all for this problem...
The last I have is this was fixed in RU6 MP1 (11.0.6100.x), I haven't seen this issue occur with that particular build. /Fingers Crossed.
Here's a few workarounds:
-Get Symdeltmp from Support
If you cannot/don't want to get this tool you can try the following:
NOTE: Please be aware this was written for Windows 7/Vista/2008. You will need to change the ProgramData folders below to C:\Documents and Settings\All Users\Application Data\Symantec\...
I apologize for the formatting, this is a copy/paste job from one of your internal KB's.
Detailed Steps:
Stop the Symantec Management Client service
•Click Start, then Run
•Type: smc -stop
•Click OK
Open the Command Prompt
•Click Start
•Click All Programs
•Click Accessories
•Right-click Command Prompt
•Click Run as administrator
•Click Yes or enter your password
Delete the contents of the User’s Temporary Folder
•Login as the user who is receiving the .tmp file detections
•From the Command Prompt, type in:
•del /F /Q %temp%
Delete the contents of the Windows Temporary Folder
•From the Command Prompt, type in:
•del /F /Q “C:\Windows\Temp”
Delete the contents of the “xfer” and “xfer_tmp” Folders
•From the Command Prompt, type in:
•del /F /Q “C:\ProgramData\Symantec\Symantec Endpoint Protection\xfer”
•del /F /Q “C:\ProgramData\Symantec\Symantec Endpoint Protection\xfer_tmp”
Delete the Quarantine Folder
•From the Command Prompt, type in:
•del /F /S /Q “C:\ProgramData\Symantec\Symantec Endpoint Protection\Quarantine”
•rd /S /Q “C:\ProgramData\Symantec\Symantec Endpoint Protection\Quarantine”
Recreate the Quarantine Folder
•From the Command Prompt, type in:
•md “C:\ProgramData\Symantec\Symantec Endpoint Protection\Quarantine”
Symantec Endpoint Protection
•Click Start, then Run
•Type: smc -start
•Click OK
Please be cautious with the use of these commands, any data in the folders that you delete will be lost forever.