Ever since our IT dept. installed SEP I've noticed problems sending email via Outlook (naive OS X client) and openning excel files. Emails can take a minute to send while an excel file can take minutes to load. I noticed a process call edpa running at 100% CPU, killing the process allows emails to be sent and files to be opened immediately. However, the edpa process will re-spawn and I'm forced to kill it each time to get emails sent and excel files loaded.
SEP (for Mac) V14 Build 1904
Outlook for Mac V15.33 (170409)
Excel for Mac V15.33 (170409)
OSX 10.12.3 (16D32)