Hello,
Check these Articles:
Best Practices for Installing Symantec Endpoint Protection (SEP) on Windows Servers
http://www.symantec.com/docs/TECH92440
About the automatic exclusion of files and folders for Microsoft Exchange server and Symantec products
http://www.symantec.com/docs/TECH102400
How to Verify if an Endpoint Client has Automatically Excluded an Application or Directory
http://www.symantec.com/docs/TECH105814
Preventing Symantec Endpoint Protection 11.0 from scanning the Microsoft Exchange 2007 directory structure
http://www.symantec.com/docs/TECH102249
Preventing Symantec Endpoint Protection 11.0 from scanning the Microsoft Exchange 2010 directory structure
http://www.symantec.com/business/support/index?page=content&id=TECH97707&locale=en_US
Configuring Symantec Endpoint Protection 11.0 exclusions for Microsoft Forefront
http://www.symantec.com/docs/TECH106465
Exclusions required to run Symantec Endpoint Protection with Windows SharePoint Services 3.0 or SharePoint Server 3.0
http://www.symantec.com/docs/TECH91287
How to exclude SQL files and folders using Centralized Exceptions
http://www.symantec.com/docs/TECH105240
What scan exclusions could be applied to an Oracle database server running Symantec Antivirus or Symantec Endpoint Protection
http://www.symantec.com/docs/TECH134383
Guidelines for choosing antivirus software to run on the computers that are running SQL Server
http://support.microsoft.com/kb/309422
For Windows Server 2008 R2, Windows Server 2008, Windows Server 2003, and Windows 2000 domain controllers
http://support.microsoft.com/default.aspx?kbid=822158
Hope that helps!!