yes it is possible, when you assign user based policy rather than system based policy.
Understanding computer and user mode in Symantec Endpoint Protection 11.0
Computer mode
The client protects the computer with the same policies, regardless of which user is logged on to the computer. The policy follows the group that the computer is in. Computer mode is the default setting.
User mode
The policies change, depending on which user is logged on to the client. The policy follows the user.
If the client software runs in user mode, the client computer software gets the policies from the group of which the user is a member. If the client software runs incomputer mode, the client gets the policies from the group of which the computer is a member.
Check rafeeq comment
https://www-secure.symantec.com/connect/forums/computer-mode-vs-user-mode-1