It is not supported but may work. You are very limited with AV solutions that are supported on Windows Home Server. SEP is an Enterprise product, so you would need to talk with a Symanec sales or authorized Symantec reseller. SEP 12 Small Business Edition is designed for smaller networks, but also lacks support for Windows Home Server.
You could always download the SEP 12 trial and see if it works for you.
https://www4.symantec.com/Vrt/offer?a_id=77956
Symantec Endpoint Protection client
Supported operating systems and platforms
- Windows 2000 Professional/Server/Advanced Server/Datacenter Server with Service Pack 3 or above
- Windows XP Home/Tablet PC/Media Center 2002/Professional/Professional x64 with Service Pack 1 or above
- Windows Vista Home Basic/Home Premium/Business/Enterprise/Ultimate (32-bit or x64 edition)
- Windows Server 2003 Standard/Enterprise/Datacenter/Storage/Web/Cluster/Small Business Server (32-bit or x64 edition), Service Pack 1 or higher.
- Windows Server 2008 Standard/Enterprise/Datacenter/Storage/Web/Core Installation (32-bit or x64 edition)
- Windows Server 2008 Small Business Server Standard and Premium/Essential Business Server Standard and Premium (32-bit or x64 edition)
- Windows 7 (32-bit or x64 edition) (New in Release Update 5)
- Windows 2008 R2 Standard/Enterprise/Datacenter/Storage/Web/Core Installation (x64 edition) (New in Release Update 5)
- Microsoft Hyper-V or VMware VMotion
- Windows XP Embedded/Windows Embedded Enterprise/Windows Embedded for Point of Service
Windows Embedded OS support requires the following minimum components: Internet Explorer 6, TCP/IP Networking, COM Base, IP Security Services, NDIS, NDIS User-mode I/O Driver, OLE Dialog Interfaces
http://www.symantec.com/business/support/index?page=content&id=TECH95178&locale=en_US
SEP 12 - http://www.symantec.com/business/products/sysreq.jsp?pcid=pcat_security&pvid=endpt_prot_sbe_1
Good luck,
Thomas