Regarding the use of IPv6 in the general of the architecture, IPv6 is currently not supported for any communication between the different SEP components themselves. All client - manager, console - manager, manager - manager traffic as well as LiveUpdate is all still based on IPv4.
It is planned to add IPv6 support for all components in the future, so that SEP can be used in pure IPv6 environments.
http://www.symantec.com/docs/TECH174897