Hi,
You would like to move the DB but without reinstalling/reconfiguring the whole SEPM setup.
There is no way.
If it would have been a SQL database:
Best Practices guide for moving the Symantec Endpoint Protection Manager SQL Server database from one drive to another on the same machine
http://service1.symantec.com/SUPPORT/ent-security.nsf/docid/2008101011093048
If Embedded Database:
(NOTE: the steps given Below are not recommended however, try at your own Risk)
Steps to move the embedded database file:
1. Click on Start> Run ,type services.msc ,click Ok
2. Stop the "Symantec Endpoint protection Manager" Service.
3. Stop the "Symantec Embedded Database" Service.
4. Click on Start> Run, type regedit and click Ok
5. Move all files in <SEPM install folder>\db folder to another folder, for example D:\Database
6. In “Registry Editor” look for the following key:
HKEY_LOCAL_MACHINE\system\currentcontrolset\services\asanys_sem5\parameters
7. Double-click on Parameters value, replace the default path with new folder which sem5.db file locate on, for example, replace ‘C:\Program Files\Symantec\Symantec Endpoint Protection Manager\db\’ with ‘D:\Database’ .
8. Close the "Registry Editor"
9. Click on Start> run>
10. Start the "Symantec Embedded Database" Service.
Warning: Do not start the "Symantec Endpoint protection Manager" Service yet.
11. Click on Start> Programs> Symantec Endpoint Protection Manager> Management Server Configuration Wizard
12. Select Reconfigure the Management and click Next step by step to finish the wizard. The wizard will take you to the final screen after re-synchronizing the application with the new database file path.