SMTP Gateway 4.6 - is this the Exchange product?
In Symantec Brightmail Gateway 9.01:
You don't need seperate IP addresses for INBOUND mail for differing domains. Even if you did, it would complicate things if you implement TLS.
1. Setup inbound interface <some IP>
2. Under Protocol, Domains, and each of your domains, mark them Local Domains, under Delivery, add [x] option route, and add the host for your INTERNAL server for this domain.
3. Update the DNS MX record for each domain to use the <some IP> used in step 1.
If you need OUTBOUND mail for each domain to appear to come from seperate IP address, use the virtual IPs under Admin, Configuration, <scanner>, SMTP, Advance settings, Delivery, and look at
"Non-Local SMTP Delivery Bindings Per Domain" On the left you'll see your local domains, on the right, your IP addresses.