Try this steps
Steps to clean Virus Definitions folders and republish Live Update Product Inventory on Symantec Endpoint Protection Manager:
Delete the content of folder "c:\documents and settings\All users\Application Data\Symantec\LiveUpdate\Downloads\"
Note: Application Data is a hidden folder. Do not delete the folder but only the contents.
Update the LiveUpdate catalog by opening the following link in Internet Explorer:
http://localhost:9090/servlet/ConsoleServlet?ActionType=ConfigServer&action=PublishLuInventory
After few seconds you will get a confirmation message "Responsecode="0".
Stop the services "Symantec Endpoint Protection Manager" and "Symantec Endpoint Protection"
To stop the services:
Go to Start > Run.
Type the following: Services.msc
Select and stop the above mentioned services.
Delete the numbered or TMP folders inside the paths:
%programfiles%\symantec\symantec endpoint protection manager\inetpub\content\{1CD85...
%programfiles%\symantec\symantec endpoint protection manager\inetpub\content\{C60DC...
%programfiles%\common files\Symantec Shared\SymcData\sesmvirdef32
%programfiles%\common files\Symantec Shared\SymcData\sesmvirdef64
%programfiles%\common files\Symantec Shared\VirusDefs
Launch the process LUALL.EXE from %programfiles%\Symantec\LiveUpdate (May be requested to click on "START")
(LiveUpdate should run for some minutes (5-10 min), if some error messages are displayed, exit and launch again LUALL.exe)
Restart both Symantec Endpoint Protection services when LiveUpdate is complete.
Verify the numbered folders of virus definitions are created in the following paths:
(There might be just 2-3 folders in the beginning, but the default number is 10 folders)
%programfiles%\symantec\symantec endpoint protection manager\inetpub\content\{1CD85...
%programfiles%\symantec\symantec endpoint protection manager\inetpub\content\{C60DC...
Log on to Symantec Endpoint Protection Manager Console and launch a LiveUpdate from Admin > Server > Local Site > Download LiveUpdate content.