PGP Desktop 10.1 is not supported for the latest version of Mac OS. In fact, even the latest version of Symantec Encryption Desktop is not supported for Sierra 10.12.3.
The System Requirements KB article for SED10.4.1 below suggests OSX 10.12.1 is the latest supported combination at this time:
http://www.symantec.com/docs/TECH236573