Sure, if you stick with machines that are 10-15 years old.
PC DOS does not recognise SATA drives. Your bios needs to have a compatibility mode which emulates the old IDE standard otherwise DOS just fails to see the drive.
PCDOS uses CHS access to hard disks. This limits the capacity you can access unless your bios has extensions, and even then there are FAT limits you will quickly hit. Modern disks use LBA to access hard disks.
PCDOS has no USB access (there are tricky solutions but all are unreliable IME)
PCDOS has memory management limits - with some DOS drivers you may need to use upper memory management to get everything loaded. Also, DOS drivers are not on every NIC manufacturer's to-do list.
PCDOS has NO idea what to do with a UEFI bios which is pretty much standard on modern machines.
Do I need to give you any more reasons???
...We also used to watch B&W TV, but I'm betting you have colour TV now.....;-)