AV, PTP, and NTP are all running on each system.
The issue is affecting both 32 and 64 bit clients, though 99% of all our machines are 32b.
They're managed clients. The SEPM is running on a 32 bit Win 2k3 SP2 server, 1 ghz cpu w/ 4 GB of RAM.
As for the version, it's 11.0.4000.2295 (not sure what MP that is or how to find that out...)
XP machines don't appear to be affected.
I'm getting a ton of normal looking DCOM 10029 events (4 to 8 a day), and a few DCOM event 10010 errors a week (which actually appear to be occuring at startup and shutdown for the most part). The DCOM errors each say something along the lines of "The server {AB8902B4-09CA-4BB6-B78D-A8F59079A8D5} did not register with DCOM within the required timeout."
I'm about to try shutting down after disabling SEP, I'll update this again in a few minutes.