Well I don't know if this will help or not but RU5 is out now and one of the "fixes" is:
With NICs that use a TCP offload engine, Symantec Endpoint Protection with Network Threat Protection enabled causes networking problems, such as connection failures and performance degradation
Fix ID: 1389258
Symptom: Teefer2 causes packet loss with TCP/UDP checksum offload by not preserving checksum data.
Solution: Teefer2 corrected to preserve checksum data.
The reason I say "fixes" is because this issue was also supposed to be fixed in MR4-MP2 and can also be found in the MR4-MP2 fixes section. It might be that they fixed it in MR4-MP2 but it was still happening in certain cases so they fixed it again with RU5. I might suggest that you upgrade a test workstation to see if you still see the packet loss on RU5.
Hope this helps
Grant