Hi,
As said on Admin Guide (page 1483):
"For example, if your company uses Skype, you can add the application to the Application Monitoring page. After you add Skype, Symantec Data Loss Prevention monitors the files sent by the client over the network."
And in "What's new" doc:
Feature Description:
You can monitor data being pasted from the clipboard to specific applications, such as the Windows Store Mail app, Google Chrome, Microsoft Lync, Microsoft Communicator, and Skype.
See “Clipboard Paste monitoring” on page 20.
As far as our company is blocking Skype, i can not test it.
Regards