1. Check for antivirus
2. Install SEP
3. Use Complex password for windows login
4. Delete or disable local admin accounts if not requred or do keep weak passwords.
5. Patch the system with MS08-067
6. use fixdowna.exe tool to remove downadup virus.
7. stop all open sharing.
This will stop infecting again & again
Regards...
Ramji Iyyer