Just ensure the SEPM serives on both/all your SEPMs are stopped while the SQL server work is carried out, and they should just connect back in afterwards.
In theory, you should only need to run the Management Server Configuration Wizard if the SEPMs are using Windows authentication for access to the DB, and that account somehow gets orphaned during the domain changes. If you're using SQL Auth, you should be fine.
Obviously take backups and whatnot.