How to make the connectivity with Active Directory or Symantec Endpoint Manager, so all client information will come from Active Directory.

Policy can be apply according to the Active Directory?

You can follow the article for the integration

How to synchronize/Integrate Active directory with the Symantec Endpoint Protection Manager (SEPM).

Edit

How to configure Symantec Endpoint Protection Manager to synchronize user data with a directory server

How to configure Symantec Endpoint Protection Manager to synchronize user data with a directory server

How to synchronize/Integrate Active directory with the Symantec Endpoint Protection Manager (SEPM).

How to setup a Symantec Endpoint Protection Manager administrator account to use Active Directory authentication

How to configure Symantec Endpoint Protection Manager to synchronize user data with a directory server

How to configure Symantec Endpoint Protection Manager to synchronize user data with a directory server

https://www-secure.symantec.com/connect/videos/importing-active-directory-sepm

Note : if you want changes for SEPM you need to change it to your AD Manually, You can't delete any computer in direct SEPM console.

SEP policies are applied from SEPM.

Reffer the article for AD integerate

http://www.symantec.com/docs/TECH181458

After integerate apply the policy as you need

Symantec Endpoint Protection Manager - Overview - Policies explained

Hello, 

You can integrate AD with SEPM to get the existing structure of your organization and make a proper plan of the policies and inheritance before doing Sync and create Sync between AD and SEPM if required.

Regards

Ajin

Check this.

Best Practices for AD Integration with SEPM

https://www-secure.symantec.com/connect/articles/best-practices-ad-integration-sepm

https://www-secure.symantec.com/connect/forums/active-directory-integration-sepm

The SEP knowledgebase is here:

http://www.symantec.com/business/support/index?page=productlanding&key=54619

Do search it for your answer