Hi Step Lason,
There could be 2 reasons, you might face compatibility issues.
1.SEP 14 MP1 and MP2 is compatible with windows 10(full protection) where as others, they are still compatible but with basic protection.
2.If it's managed client, pushing existing package or manual installation of existing package cause compatibility issue, as there could be a broken package. Broken package leads to compatibility issues.
Regards,
Sunray.