JDavis,
the installation manual states that AV updates are on port 80 outbound, but don't mention the spam filter port. Install Guide, page 94. Are the spam filters on the 80/443 as well? Documentation update?
Web addresses & Port Symantec Brightmail Gateway uses
URL Protocol Port Description
swupdate.brightmail.com TCP 443 Used to retrieve new software
register.brightmail.com TCP 443 Used to register the appliance
aztec.brightmail.com TCP 443 Used to retrieve filters
liveupdate.symantecliveupdate.com TCP 80 Default automatic antivirus updates
liveupdate.symantec.com TCP 80 Default automatic antivirus updates
relay.msg.yahoo.com TCP 80 Yahoo file transfer
definitions.symantec.com TCP 80 Rapid response antivirus updates