Run the symhelp tool on an affected client. Also enable sylink debugging and let it run for a bit. Post the log for review.
Troubleshooting computer issues with the Symantec Help support tool
http://www.symantec.com/docs/HOWTO80839
How to enable Sylink debugging for the Symantec Endpoint Protection 11.x and 12.1 client in the Windows Registry
http://www.symantec.com/docs/TECH104758