With more research it seems it's a scan related issue.
1. Configure Defwatch: It can be resolved by configuring Defwatch to not rescan quarantine:
2. Disable the Windows Indexing Service
What happens when indexing “touches” a file placed in the %temp% or I2_LDVP.tmp folder that it has not indexed yet?
Large files that are too big to fit in memory are placed in the %temp% or I2_LDVP.tmp folder for scanning. Once the file exists in the folder, indexing needs to update itself and touches the file.
Because the “touch” changes the file it becomes a different file to SAV/SEP and the scanning loop starts.
Symantec's recommendation is to disable Windows Indexing, however if this cannot be implemented for customer reasons, then reconfigure Windows Indexing it to exclude the SAV/SEP files and folders in all locations.
Windows Indexing can be configured to not index specific files and folders.
http://support.microsoft.com/kb/308202